Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels and risk of lung cancer in EPIC Running title: 15q25 and 19q13 loci, cotinine levels and lung cancer risk
نویسندگان
چکیده
Maria N. Timofeeva, James D. McKay, George Davey Smith, Mattias Johansson, Graham B. Byrnes, Amélie Chabrier, Caroline Relton, Per Magne Ueland, Stein Emil Vollset, Øivind Midttun, Ottar Nygård, Nadia Slimani, Isabelle Romieu, Françoise ClavelChapelon, Marie-Christine Boutron-Ruault , Guy Fagherazzi 8,9,10 Rudolf Kaaks, Birgit Teucher, Heiner Boeing, Cornelia Weikert, H Bas Bueno-de-Mesquita, Carla van Gils, Petra HM Peeters, Antonio Agudo, Aurelio Barricarte, Jose-Maria Huerta, Laudina Rodríguez, Maria-José Sánchez, Nerea Larrañaga, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Ruth C Travis, Valentina Gallo, Teresa Norat, Vittorio Krogh, Giovanna Masala, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Torgny Rasmuson, Göran Hallmans, Elio Riboli, Paolo Vineis , Paul Brennan
منابع مشابه
Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
BACKGROUNDS Multiple polymorphisms affecting smoking behavior have been identified through genome-wide association studies. Circulating levels of the nicotine metabolite cotinine is a marker of recent smoking exposure. Hence, genetic variants influencing smoking behavior are expected to be associated with cotinine levels. METHODS We conducted an analysis in a lung cancer case-control study ne...
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Recent studies identified three genetic loci reproducibly associated with lung cancer in populations of European ancestry, namely 15q25, 5p15 and 6p21. The goals of this study are first to confirm whether these loci are associated with lung cancer in a French Canadian population and second to identify disease-associated single nucleotide polymorphisms (SNPs) influencing messenger RNA (mRNA) exp...
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There is widespread agreement that self-reported smoking quantity, though a convenient and simple measure, is an imprecise assessment of exposure to tobacco smoke and that measuring serum cotinine levels in cigarette smokers provides a more objective estimate of current smoking behavior. Initial genome-wide association studies (1–3) suggested that single-nucleotide polymorphisms (SNPs) spanning...
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